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Join us at www. Now you can find the tools you need to help manage your patients, all in one place! KISQALI has been shown to prolong the QT interval in a concentration-dependent manner, with estimated mean increase in Free weight loss pills with free shipping and handling uk interval exceeding 20 ms In MONALEESA-2, one patient 0. These ECG changes occurred within the first 4 weeks of treatment and were reversible with dose interruption.

There were no reported cases of torsades de pointes. Syncope occurred in 9 patients 2. Hepatobiliary toxicity In MONALEESA-2, increases in transaminases were observed. Febrile neutropenia was reported in 1. Treatment discontinuation due to neutropenia was 0. Based on the observed QT prolongation during treatment, KISQALI may require dose interruption, reduction, or discontinuation. East Hanover, NJ: Novartis Pharmaceuticals Corp; Important Safety Information QT Fat burn thc prolongation.

These electrocardiogram ECG changes occurred within the first 4 weeks of treatment and were reversible with dose interruption. Assess ECG prior to initiation of treatment. Repeat ECG at approximately Day 14 of the first cycle, at the beginning of the second cycle, and as clinically indicated. Monitor serum electrolytes including potassium, calcium, phosphorus, and magnesium prior to the initiation of treatment, at the beginning of each of the first 6 cycles, and as clinically indicated.

Correct any abnormality before starting therapy with KISQALI. In MONALEESA-2, increases in transaminases were observed. Perform liver function tests LFTs before initiating therapy with KISQALI. Monitor LFTs every 2 weeks for the first 2 cycles, at the beginning of each of the subsequent 4 cycles, and as clinically indicated. Based on the severity of the transaminase elevations, KISQALI may require dose interruption, reduction, or discontinuation. Perform complete blood count CBC before initiating therapy with KISQALI.

Monitor CBC every 2 weeks for the first 2 cycles, at the beginning of each of the subsequent 4 cycles, and as clinically indicated. Based on the severity of the neutropenia, KISQALI may require dose interruption, reduction, or discontinuation. Based on findings from animal studies and the mechanism of action, KISQALI can cause fetal harm when administered to a pregnant woman.

In animal reproduction studies, administration of KISQALI to pregnant rats and rabbits during organogenesis caused embryofetal toxicities at maternal exposures that Free weight loss pills with free shipping and handling uk 0. Advise pregnant women of the potential risk to a fetus. Advise women of reproductive potential to use effective contraception during therapy with KISQALI and for at least 3 weeks after the last dose. Please see full Prescribing Information.

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This site is for US health care professionals only. KISQALI FEMARA Co-Pack Prescribing Info. QT interval prolongation KISQALI has been shown to prolong the QT interval in a concentration-dependent manner with estimated mean increase in QTc interval exceeding 20 ms


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