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N Engl J Med ; March 31, DOI: Full Text of Background In this 1-year, randomized, controlled trial, we evaluated the independent and combined effects of weight loss and exercise in adults who were 65 years of age or older and obese. Participants were randomly assigned to a control group, a weight-management diet group, an exercise group, or a weight-management-plus-exercise diet—exercise group. The primary outcome was the change in score losss the modified Physical Performance Test.
Secondary outcomes included other measures of frailty, body composition, bone mineral density, specific physical losd, and quality of life. Full Text of Methods Adverse events included a small number of exercise-associated musculoskeletal injuries. Full Text of Results These findings suggest that a combination of weight loss and exercise provides greater improvement in physical function than either 965 weight loss alone.
Funded by the National Institutes of Health; ClinicalTrials. Full Text of Discussion Obesity in older adults is becoming a serious public health problem in the United States. We now report the results of a randomized, controlled trial 965 weight loss was designed to determine the independent and combined effects of 965 weight loss weight loss and regular exercise on physical function, body composition, and quality of life in obese older adults.
965 weight loss hypothesized that weight loss and exercise would each improve physical function and that the combination of the two would result in the greatest improvement in physical function and amelioration of physical frailty. We conducted the study from April through August at the Washington University School of Medicine. The study was approved by the institutional review board and was monitored by an independent data and safety monitoring board.
The protocolincluding the statistical analysis plan, is available with the full text of this article at NEJM. All the authors vouch for the data and analyses, as well as the fidelity of the study to the protocol. The first author wrote the first draft of the manuscript; all the authors participated in writing subsequent drafts and made the decision to submit the manuscript for publication. Volunteers were recruited through advertisements, and each participant provided written informed consent.
Potential participants underwent losw comprehensive medical screening procedure. Volunteers were eligible for inclusion in the study if they wight 65 years of age or older and obese BMI [the weight in kilograms divided Weight loss center aurora illinois the square of the height 965 weight loss meters] of 30 or moreif they had a sedentary lifestyle, if their body weeight had been stable during the 965 weight loss year i.
All participants had to have mild-to-moderate frailty, on the basis of meeting at least two of the following operational criteria 8,19,20 : a score on the modified Physical Performance Test in which the total score ranges from 0 to 36, with higher scores indicating better physical status of 18 to 32; a peak oxygen consumption VO 2peak of 11 to 18 ml per kilogram of body weight per minute; or difficulty in performing two instrumental activities of daily living or one basic activity of daily living.
Persons who had severe cardiopulmonary disease; musculoskeletal or neuromuscular impairments that preclude exercise training; visual, hearing, or cognitive impairments; or a history of cancer, as well as persons who were receiving drugs that affect bone health and metabolism or who were current smokers, were excluded. The primary outcome 965 weight loss the change from baseline in the score on the modified Physical Performance Test. Frailty was with the use of the modified Physical Performance Test, the measurement of VO 2peakand the Functional Status Questionnaire.
The modified wegiht Performance Test includes seven standardized tasks walking 50 ft, putting on and removing a coat, picking up a penny, standing up from a chair, lifting a book, climbing one flight of stairs, and 965 weight loss a progressive Romberg test plus two additional tasks climbing up and down four flights of stairs and performing a degree turn.
965 weight loss
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